Barcelona are the more desperate side as Real Madrid visit Camp Nou on Saturday for the first El Clasico of the season with a six-point lead at the top of La Liga.
Real Madrid is currently in a 31-game unbeaten run in all competitions.
“On Saturday we have more to play for than Madrid, they can lose, we can’t,” said Barcelona defender Gerard Pique.
Barca are off to their worst league start in nine seasons.
However, coach Luis Enrique believes much of the media criticism of his side has been overblown, citing the institutional crisis that Barca overcame in the January his debut season in 2015 to win the treble.
“We remain favourites for all the titles, but it is evident we have to improve,” said Enrique.
“We lack consistency, but don’t exaggerate. In my first season you (the media) exaggerated and we ended up winning the treble.”
The biggest match in club football is expected to capture an audience of 650 million people worldwide, according to figures released by La Liga.
“I am not going to say it is just another game, it is a very important match, it has a special meaning….a special taste,” Real president Florentino Perez told AFP.
“No one hides that is has a worldwide impact, it is seen by millions of people across the world, like the World cup final.”
Yet, the composed Zidane refused to accept that a first Liga title in five years would be Madrid’s to lose should they bag victory at the Camp Nou.
“I am not thinking about the consequences,” he said after giving a goalscoring debut to his son Enzo in Madrid’s 6-1 Copa del Rey thrashing of Cultural Leonesa on Wednesday.
“We are thinking about preparing well for the game, and, whatever happens, it will not be decisive.”